Methotrexate; Evaluation of the effects on reproduction, recommendation for classification

In the present report, the Health Council of the Netherlands reviewed methotrexate. Methotrexate is used to induce (i.e. non-surgical) abortions in very early pregnancies and to treat ectopic pregnancies, various cancers, rheumatoid arthritis and other inflammatory rheumatic disorders, and psoriasis. This report is part of a series, in which the Health Council evaluates the effects of substances on reproduction, at the request of the Minister of Social Affairs and Employment.