Tricresylphosphate: Evaluation of the effects on reproduction, recommendation for classification

Tricresylphosphate (TCP) is used as a flame retardant in polystyrene and other thermoplastics, as a PVC plasticiser, lubricant and as hydraulic fluid. It is used in occupational settings such as in the media printing industry, formulation of mixtures and scientific research. TCP is also used as additive in turbine engine oil.

At request of the Minister of Social Affairs and Employment, the Subcommittee on the Classification of Substances Toxic to Reproduction of the Dutch Expert Committee on Occupational Safety of the Health Council has evaluated the effects of tricresylphosphate on reproduction. To assess effects on reproduction, the Committee evaluates the effects on male and female fertility, on the development of the offspring, on lactation and on the offspring via lactation.

Based on the available scientific data, the Committee recommends classifying the substance tricresylphosphate as suspected to be a reproductive toxicant to humans, which corresponds with category 2 (suspected of damaging fertility). There is limited evidence for effects on fertility. The Committee recommends not to classify tricresylphosphate for developmental toxicity and for effects during lactation due to lack of appropriate data.